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Oprah Winfrey Shows Off Her Slimmer Physique While Plugging A New Weight Loss Book After Admitting To Taking GLP-1 Medication: ‘I Feel More Alive Than I’ve Ever Been’

January 2, 2026 by Abigail Connolly

 
Splash News

Oprah Winfrey is one of the many celebrities in Hollywood who have undergone a drastic transformation in the last few years, and she’s recently given an in-depth update to her fans.

The talk show host is one of People Magazine’s latest cover stars, and in her interview, she opened up about her weight loss journey in honor of a book she co-wrote on obesity. She gave an update on her experiences with using a GLP-1 medication, her favorite kind of exercise these days, and more. Read more about what she had to say below.

Oprah Winfrey Promotes Her New Book On Obesity In A New 'People' Cover Interview

These days, with the rise of GLP-1 medications, there have been more and more stars stepping out with slimmer figures and weight loss transformations. However, one of the most prominent has always been the Color Purple actress, who has been working on her health and weight all throughout her career.

Over the last few years, however, she's found a sweet spot and has maintained her weight loss, opening up about how she's feeling and looking better than ever. Now, in a new People cover story interview, she's sharing more information on her journey as well as looking further into obesity and how people can manage it these days in a book that she co-wrote alongside obesity expert Dr. Ania M. Jastreboff, Enough: Your Health, Your Weight and What It's Like to Be Free.

The book comes out on January 13th, and not only takes a look at how people can use modern medicine and techniques to lose excess weight and tackle obesity, but also how, there's oftentimes more to obesity than a poor diet and lack of exercise, stressing that it's not always a "choice."

"I thought it was about discipline and willpower," she told the publication. "But I stopped blaming myself."

Oprah Gives An Update On Her GLP-1 Experience & Shares Her Favorite Forms Of Exercise

In addition to promoting her new book release, the philanthropist gave the publication an update on her usage of a GLP-1 medication, which has caused some buzz on the internet. After years of dieting and trying new nutrition programs, Oprah has mentioned that being able to take a GLP-1 has been a game-changer when it comes to maintaining her weight loss versus struggling with gaining it back.

After calling the drugs "a gift" in 2023, she revealed that she now uses it as "a tool to help you manage the messages that are being sent to your brain about overeating," taking it weekly or every 10 to 12 days. She acknowledged that it's now a "lifetime thing," and that she began taking the drugs "gradually" in order to get the maximum effects. In addition to taking the medication, she also works out six days a week, enjoying hiking, cardio, resistance training, and more.

Now, the award-winning host is thriving and told the magazine, "I feel more alive and more vibrant than I've ever been."

"If you have obesity in your gene pool, I want people to know it's not your fault," she added. "I want people to stop blaming themselves for genes and an environment they can't control. I want people to have the information, whatever you choose to do with it, whether you get the medications, or whether you want to keep dieting."

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