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Want To Slow Down Aging After 50? Doctors Share The 3 Supplements That Can ‘Reverse Biological Clock’

September 26, 2025 by Mariam Qayum

 
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Aging is a natural part of life, but many people over 50 are looking for ways to not just look younger, but actually feel younger from the inside out. While no supplement can stop time, certain nutrients have been shown to support cellular health, boost energy, and even help slow down the effects of aging at the biological level. Doctors say that a few key supplements may actually help “turn back the clock” by protecting your body against oxidative stress, inflammation, and age-related decline. If you want to stay sharp, energetic, and vibrant well into your later years, these three powerhouse supplements may be worth adding to your daily routine.

1. Nitric Oxide

Nitric oxide might sound like a science experiment, but it’s actually a powerful gas that helps open up your blood vessels, improving circulation and overall cardiovascular health. Harvard-trained doctor and anti-aging expert Dr. Josh Helman’s go-to supplement for this is Nitric Oxide, which supports blood flow and helps maintain youthful energy levels. Better circulation means your organs and muscles get more oxygen and nutrients—key to staying vibrant as you age.

2. NMN (Nicotinamide Mononucleotide)

NMN is a mouthful, but this compound is a rising star in the anti-aging world. It helps boost levels of NAD+, a vital molecule involved in energy metabolism and cellular repair. Increasing NAD+ is linked to improved longevity and healthier cells. Unlike typical supplements, NMN targets the root of aging on a cellular level, supporting energy production and overall vitality.

3. Honokiol: The ‘Biological Clock Reverser’

One of the most exciting supplements on Dr. Helman’s list is Honokiol. He calls it a great way to reverse your biological clock. Though less commonly known, Honokiol is gaining attention for its potential to rejuvenate cells and promote anti-aging benefits. Taking this supplement could help you feel younger from the inside out by addressing the aging process itself.

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