Feeling foggy or forgetful? According to Dr. Sanil Rege, a psychiatrist and educator, intermittent fasting might be the key to boosting your brainpower.
“Most people think that skipping meals makes you sluggish,” says Dr. Rege. “However, research suggests that fasting may enhance brain function, promote neuroplasticity, enhance cognitive resilience, and improve metabolic efficiency.”
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The Brain-Boosting Science of Fasting
While the modern world revolves around three square meals a day (plus snacks), our ancestors lived a very different reality.
“Our ancestors never had constant access to food,” Dr. Rege explains. “Some days they feasted on fresh meat. Other days they had nothing. And yet their brains didn't shut down.”
In fact, the human body is designed to operate in two metabolic modes. In times of plenty, we rely on glucose metabolism—our quick-burning fuel. But when food is scarce, our bodies switch gears.
“We shift into what’s called ketone metabolism,” says Dr. Rege. “Instead of feeling weak, the body enters a state known as ketosis.” During ketosis, fat cells release free fatty acids into the bloodstream. The liver then converts these into ketones, specifically beta-hydroxybutyrate (BHB) and acetoacetate (ACAC). The brain, rather than slowing down, adapts by using ketones as fuel.
Fueling the Brain’s Growth
One of the most intriguing effects of ketosis is its impact on brain-derived neurotrophic factor (BDNF)—a protein often described as “fertilizer for the brain.”
“Ketosis increases brain-derived neurotrophic factor,” Dr. Rege says. “BDNF strengthens neural connections, enhances learning and memory, and protects against cognitive decline.”
This means that far from being detrimental, periods of fasting may give the brain a chance to reset and recharge—improving focus, clarity, and long-term resilience.
The Bottom Line
Intermittent fasting is more than a trendy diet. It’s a biologically rooted way of eating that taps into our evolutionary design. And according to experts like Dr. Rege, it may hold real promise for supporting mental clarity, sharpening memory, and even protecting the brain as we age.
As always, consult your healthcare provider before making any major changes to your diet or lifestyle.
