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4 Supplements That Could Be Wrecking Your Sleep, According To A Neurologist: Vitamin D, More

June 27, 2025 by Abigail Connolly
shefinds | Health
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When you start taking a certain supplement, some people may believe that it’s best to start taking it at nighttime, before bed. While that may apply to some, it’s not always the case.

A neurologist and TikTok content creator, Dr. Alan Mandell, made a video about three supplements that “you shouldn’t take before bed,” as they can disrupt your sleep. Not getting enough sleep has a significant impact on our bodies, as it can cause trouble focusing, stress, weight gain, and other irritating symptoms. Read more about Dr. Mandell’s three vitamins that should be avoided at bedtime below.

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Vitamin B12 capsules for energy and wellness support.

 Vitamin B-12

Dr. Mandell says that vitamin B-12 is "vital for energy production and brain function," but that it should be taken at another time besides right before bed. In fact, many people take B-12 because they have issues with fatigue or trouble focusing, so it would make sense not to take it before trying to get a good amount of sleep at night.

 

"B-12 can be very stimulating to the central nervous system, and that can disrupt your sleep," he adds.

Golden Vitamin D pill for healthy bones and immunity.

Vitamin D

Vitamin D is often called the 'sunshine' vitamin, and is popular for helping out our bone and immune health. Many elderly people take it for osteoporosis, but anyone can begin taking it, especially if they've been told they have a deficiency by their doctor.

 

"Vitamin D is essential for bone and immune health," explains Dr. Mandell.

 

"But vitamin D can interfere with melatonin production, the hormone that regulates our sleep, potentially leading to difficulty falling asleep and staying asleep."

Vitamin C pills for antioxidant protection and skin health.

Vitamin C

Many of us are taking vitamin C these days, as it's known to be very supportive of our immune systems, and people tend to get in as much as possible in fear of getting a cold. However, taking it before bed can cause issues, and they don't have to do with your energy levels.

 

"Vitamin C is also known for boosting your immune system, but [it] can cause gastrointestinal discomfort, and if you're taking this before lying down, in some cases, this may give you that mild stimulatory effect, making it challenging to relax before sleep," notes Dr. Mandell.

Yellow Vitamin E capsule promoting skin and heart health.

Vitamin E

Unfortunately, while vitamin E can be very beneficial to our hair and skin, it can also cause some stomach issues when taken before bed.

 

"Vitamin E sometimes can cause gastrointestinal issues as well," says Dr. Mandell. "It can be uncomfortable and disruptive during the night."

The Bottom Line

If you want the best results from these vitamins and supplements and don't want to risk losing any sleep, Dr. Mandell suggests taking them "earlier in the day." For instance, you can kick off your morning by taking your supplements along with your daily cup of coffee.

 

"[They] will give you lots of energy, keep you focused, and most importantly, keep you healthy," he adds.

Author:

Editorial Assistant

Abigail is a journalist based in Brooklyn, New York. As an Editorial Assistant for SheFinds, she covers topics ranging from celebrity news and fashion to wellness. She has written for other publications, including Chip Chick, Bandsintown, BroadwayWorld, and more. When she isn't writing, Abigail loves spending time in the city with her friends, being a 'dog mom' to her Chihuahua, and singing along to some of her favorite music.

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Handful of dietary supplements for optimal nutrition.
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Close-up of supplement powder being poured into a glass.
Woman exercising outdoors for fitness.
Exhausted woman sipping coffee for a quick energy boost
Display of deli meats and sandwiches in a grocery store.
Person enjoying a healthy lunch at a dining table.
Enjoying spearmint tea for potential skin benefits.
Frustrated older woman holding her head in distress.
Woman experiencing chest pain, highlighting health concerns.
Various types of bread displayed on a wooden surface.
Woman holding her head, feeling overwhelmed or stressed.
Woman experiencing joint pain, indicating health issues.
Popular fast food options from Dunkin', Chick-fil-A, and Starbucks.
Woman adding sugar to her aromatic cup of coffee.
Assorted bagels with blueberries and butter on a wooden board.
Pouring vitamin D into palm for health.
Comparing cooking spray and olive oil for healthy cooking.
Older woman taking supplements with water for wellness.
Top view of Brazilian food dish with rice, beans, and chicken.
Handful of dietary supplements for optimal nutrition.
Checking time on a watch during breakfast.
Close-up of supplement powder being poured into a glass.
Woman exercising outdoors for fitness.
Exhausted woman sipping coffee for a quick energy boost
Display of deli meats and sandwiches in a grocery store.