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5 Supplements That Could Actually Be Harmful To Your Pancreas, According To Doctors: Bitter Orange & More

August 23, 2025 by Faith Geiger
shefinds | Health
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You may assume that “natural” equals “safe,” especially when it comes to supplements, which are meant to give your health a simple boost. Unfortunately, though, the truth is that many supplements can come with serious risks. Even herbal options can cause damage to your organs, including your pancreas.

“Among the riskiest supplements for the pancreas are those that are marketed for detox or fat burning,” warns Dr. Jefferey Chester, DO, Medical Director at The Ohana Luxury Addiction Treatment Center. “These often put stress on the pancreas.” We spoke to Dr. Chester to learn about a few of the most dangerous options, from bitter orange to seemingly harmless vitamin D. Find all of his warnings below.

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bitter orange

1. Bitter Orange

While it may be touted as a good option for fat-burning, bitter orange may do more harm than good. "It can raise heart rate and blood pressure. This can place stress on the pancreas," explains Dr. Chester. Instead of relying on quick fixes, he recommends focusing on sustainable lifestyle changes. "A safer alternative for weight management is to focus on exercise and diet changes. You can also talk to your doctor about FDA-approved medications for weight loss."

green tea extract

2. Green Tea Extract

While sipping green tea is generally highly beneficial, its concentrated supplement form is another story. "This can be a risk to the pancreas in high doses. Concentrated green tea extract has been linked to pancreatitis. It can be toxic to the liver," Dr. Chester cautions. As with anything, moderation is key. "You can drink green tea in moderation. Matcha is also fine in moderation, as well. This provides antioxidants without stressing the pancreas."

vitamin d

3. Vitamin D (in High Doses)

Vitamin D is essential for bone health, mood, and immunity—but more isn’t always better. "High doses of vitamin D can be toxic. It can lead to organ inflammation. This may affect the pancreas," says Dr. Chester. "It’s safer to take only the recommended daily allowances of vitamin D. Before supplementing, consider getting your levels checked with your physician to see if it’s even necessary."

herbal supplements

4. Valproic Acid-Containing Herbal Blends

Some supplements marketed for mood support contain compounds similar to prescription medications. "These supplements are often marketed for mood issues. The problem is that they can mimic the prescription of valproic acid, which is linked to pancreatitis," Dr. Chester explains. If you’re struggling with low-mood, he recommends alternative methods over supplementation: "An alternative…is to seek help from a medical or mental health professional. Many evidence-based treatments for mood issues are safe and effective." Got it!

detox tea

5. Detox and Fat-Burning Supplements in General

Beyond the specific examples, Dr. Chester warns that detox teas, fat-burning pills, and other "quick-fix" formulas are among the most dangerous. "Among the riskiest supplements for the pancreas are those that are marketed for detox or fat burning," he notes. They can contain multiple stimulants or herbal compounds that overstress the pancreas. Instead of turning to these harmful supplements, stick to a healthy diet, regular exercise, and care from your doctor. Because supplements don't work miracles.

Author:

Freelance Writer

Faith Geiger is a New York-based writer and editor. When she's not covering the latest in health and wellness for SheFinds, she spends her time watching reality TV with her roommates, browsing used bookstores, and enjoying live music. You can reach Faith at faithkgeiger@gmail.com.

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Variety of bread types showcased on a table.
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Variety of fast food from Dunkin', Chick-fil-A, Starbucks.
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Tasty bagels with blueberries and butter on a wooden board.
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Handful of assorted dietary supplements in palm.
Close-up of watch as someone eats breakfast.
Pouring supplement powder into a glass of water.
Woman performing yoga on a mat in a studio
Woman drinking coffee to combat extreme fatigue.
Display of deli meats, sandwiches, hot dogs, and sausages.
Person having a lunch meal.
Enjoying spearmint tea for potential skin benefits.
Frustrated older woman touching her head in distress
Woman experiencing chest pain, seeking medical attention
Variety of bread types showcased on a table.
Woman holding her head, expressing stress.
Woman experiencing joint pain while sitting.
Variety of fast food from Dunkin', Chick-fil-A, Starbucks.
Woman adding sugar to a steaming cup of coffee.
Tasty bagels with blueberries and butter on a wooden board.
Pouring vitamin D into palm for healthy skin benefits.
Comparison of cooking spray and olive oil for healthy cooking.
Older woman taking dietary supplements with water.
Brazilian dish featuring rice, beans, and chicken from above.
Handful of assorted dietary supplements in palm.
Close-up of watch as someone eats breakfast.
Pouring supplement powder into a glass of water.
Woman performing yoga on a mat in a studio
Woman drinking coffee to combat extreme fatigue.
Display of deli meats, sandwiches, hot dogs, and sausages.