Tretinoin is one of the most powerful anti-aging ingredients in skincare, known for its ability to stimulate collagen production, smooth fine lines, and improve overall skin texture. For the eye area, it can work wonders, helping to reduce the depth of wrinkles and improve elasticity. But dermatologists caution that the delicate skin around your eyes requires special care when using tretinoin, as it can be surprisingly drying and irritating.
Board-certified dermatologist Dr. Dray explains, “Tretinoin can be amazing for improving wrinkle depth around the eyes because it improves collagen production. It can be very drying and irritating, especially in the beginning and especially on delicate eyelid skin.” The thin skin on the eyelids is more sensitive than other areas of the face, which means the risk of redness, flaking, and irritation is higher.
@drdrayzday Tretinoin & getting rid of wrinkles around the eyes. #eyewrinkles #tretinoin #crowsfeet #retinol #antiagingskincare #dermatologist @Jaime Darretta original sound – Dr Dray | Dermatologist
Preventing Eye Wrinkles While On Tretinoin
To prevent these side effects, Dr. Dray recommends applying a skin protectant to the eyelids before applying tretinoin to the rest of your face. She shares that she currently uses La Roche-Posay Gel B5 Cicaplast, but simpler options like petroleum jelly work just as well. “You want to improve the appearance of wrinkles around the eyes similar to tretinoin, but with less risk of dryness and irritation,” she says.
For those hesitant to use tretinoin near the eyes, Dr. Dray suggests alternative forms of vitamin A, such as retinol in an eye cream or retinaldehyde, which are gentler but still help support collagen production. These cosmetic options provide anti-aging benefits without the same level of irritation that stronger prescription retinoids can cause.
Stick To Hydration
Hydration is another key factor in preventing fine lines from becoming more pronounced. “Consistently moisturizing eyelid skin also can make those little fine crepey lines look a lot less obvious simply through hydration,” Dr. Dray notes. Look for creams or gels that contain humectants like hyaluronic acid or glycerin, which draw water into the skin and help maintain a plump, youthful appearance.
Other tips to protect your eye area include avoiding harsh rubbing when applying products, using a gentle patting motion instead of pulling or tugging, and always wearing sunscreen. The skin around your eyes is highly susceptible to UV damage, which accelerates collagen breakdown and can undo the benefits of your anti-aging routine. Pairing sun protection with proper hydration and careful use of tretinoin can make a huge difference in the long-term health of the eye area.
Dr. Dray emphasizes that treating your eyes with care doesn’t mean skipping anti-aging treatments entirely. With the right techniques and protective measures, tretinoin and vitamin A derivatives can help reduce wrinkles, improve texture, and keep your eye area looking youthful — without causing extra dryness or irritation.
The bottom line? Your eye area deserves thoughtful attention, not the same routine you use on the rest of your face. Using a protective ointment, hydrating consistently, and choosing the right form of vitamin A can help you get the anti-aging benefits you want while keeping your delicate eyelid skin safe.


