From skincare routines to in-office treatments, anti-aging is often framed as something you apply topically. But more experts are now pointing to what you take internally as just as important. In a recent conversation, neuroscientist Robert Love sat down with Dr. Josh Helman, a Harvard-trained medical doctor, to discuss the supplements they believe have real science-backed anti-aging potential.
Rather than focusing on trendy powders or quick fixes, the two highlighted supplements that support inflammation reduction, cellular energy, circulation, and overall biological aging—key factors that influence how we age both inside and out.
Here are the five anti-aging supplements they say actually work.
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1. Honokiol
Dr. Helman names honokiol as his top anti-aging supplement, pointing to its powerful anti-inflammatory properties. Chronic inflammation is widely linked to faster aging, dull skin, and overall cellular decline. According to Helman, honokiol helps reduce inflammation and may even support improvements in biological age, making it a standout option for longevity-focused routines.
2. Creatine
Often associated with fitness and muscle-building, creatine is described as one of the most underrated anti-aging supplements on the list. Dr. Helman explains that beyond supporting muscle strength, creatine may help “turn back the biological clock.” He also points to emerging research suggesting benefits for brain health and memory, which become increasingly important with age.
3. Nitric Oxide
Nitric oxide plays a key role in circulation by helping blood vessels relax and open. Better blood flow supports healthier skin, improved oxygen delivery, and overall vitality. While the body produces nitric oxide naturally, Dr. Helman notes it can be supported through diet—particularly by consuming leafy greens and beets, which help boost nitric oxide levels.
4. Pectin (Modified Citrus Pectin)
Modified citrus pectin is highlighted for its ability to bind to heavy metals and environmental toxins, which can accelerate aging and inflammation. Dr. Helman explains that by helping the body eliminate these toxins, pectin may also support healthier cellular function and contribute to improvements in biological aging over time.
5. NMN (Nicotinamide Mononucleotide)
The most important supplement on the list, according to Dr. Helman, is NMN. He explains that NMN supports the production of NAD, a compound essential for cellular energy and mitochondrial function. NAD levels naturally decline with age, and restoring them may help support the body’s core aging pathways. Helman notes that these pathways are shared across many living organisms, which is why NMN has become such a major focus in longevity research.
The Bottom Line
While no supplement can replace sunscreen, skincare, or healthy lifestyle habits, experts increasingly agree that aging starts at the cellular level. Supporting inflammation control, circulation, detoxification, and energy production from within may help skin look brighter, firmer, and more resilient over time. As always, supplements should be approached thoughtfully and discussed with a healthcare professional—but these five are gaining attention for a reason.
