If you’re looking to live longer, age gracefully, and protect your body from disease, there’s one supernutrient you may want to start adding to your plate: fisetin. According to Dr. Shantani, MD—a Harvard-trained nutritionist—this plant compound could be a game-changer for both longevity and youthfulness.
“A major cause of physical aging is the accumulation of old cells that can lead to cancer and cause aging of the skin,” Dr. Shantani explained in a recent Instagram video. “These cells should be recycled in a process called autophagy or apoptosis. This makes way for healthier, more youthful cells.”
Fisetin has been shown to trigger this essential cellular recycling process. In fact, Dr. Shantani points to studies on mice, saying, “When given this nutrient, mice lived 10 percent longer than expected.” But that’s just the beginning of what this compound can do.
Here are five reasons he says fisetin helps preserve youth and may extend lifespan:
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1. It Clears Out Old Cells Fisetin helps induce autophagy and apoptosis, the processes that clear out old, damaged cells. “This makes way for youthful cells and skin,” he said.
2. It Activates Longevity Genes “This nutrient turns on sirtuins, or longevity genes,” Dr. Shantani shared. These genes play a key role in regulating aging and cellular repair.
3. It’s Powerfully Anti-Inflammatory Chronic inflammation is linked to nearly every age-related disease. According to Dr. Shantani, fisetin “has powerful anti-inflammatory effects” that help lower this risk.
4. It Fights Cancer Another perk? Fisetin may help stop tumors from growing. “It has anti-angiogenesis, anti-cancer effects,” he noted, referring to its ability to cut off a tumor’s blood supply.
5. It Boosts Brain Health Aging doesn’t just affect the body—it can slow your mind too. But fisetin helps there as well. “It preserves brain function and increases synaptic density,” said Dr. Shantani, which may improve memory and focus.
Where to Find It
You don’t need a supplement to reap the benefits of fisetin. Dr. Shantani recommends loading up on fruits like strawberries, apples, persimmons, onions, and grapes. “To preserve your youthfulness, try these foods,” he said.
His parting advice? “My goal is to help you have great health for up to 120 years.” And with powerful plant nutrients like fisetin in your corner, it might just be possible.
