The supplements overflowing on pharmacy shelves are certainly tempting; wouldn’t it be amazing to take a single magic pill for all of your health issues? On one hand, certain supplements can be beneficial to your health. However, it’s always crucial to take your supplements with a grain of salt. Many of them can be straight up ineffective, but worse than that, several options can be dangerous, posing serious risks to your health and safety if you’re not careful.
Many people assume that because supplements are labeled as “natural,” they are inherently safe. However, experts warn that certain supplements may increase the risk of blood clots, among other risks. This is particularly concerning for individuals with a history of clotting disorders, those taking hormonal therapy, pregnant women, or anyone at high risk for cardiovascular disease. Blood clots could lead to serious health conditions such as deep vein thrombosis (DVT), strokes, or heart attacks.
According to Dr. Mario Padron, a physician and health expert, it’s integral to be aware of how supplements interact with the body, especially for those on anticoagulant medications. “If you have a history of clotting disorders, take hormonal therapy, are pregnant, or are at high risk for cardiovascular disease, you need to be especially cautious.” But what are the supplements to be wary of? Find Dr. Padron’s warnings regarding five common choices below.
1. Vitamin K
On one hand, Vitamin K is essential for several of factors of your health, including the fact that it plays a crucial role in blood clotting, making it essential for wound healing. However, excessive intake of Vitamin K supplements can increase the risk of blood clots—especially if you have preexisting cardiovascular conditions.
"Vitamin K is essential for blood clotting, which is why it’s often used to counteract blood thinners. However, excessive vitamin K intake—especially from supplements—can thicken the blood and increase clot risk," Dr. Padron warns. This is especially concerning for anyone taking anticoagulant medications like warfarin, as high vitamin K levels can make these drugs less effective. Whenever possible, get your vitamin K from the foods you eat, like leafy greens, rather than supplements.

2. Iron Supplements
Just as with Vitamin K, iron is undeniably essential to your wellbeing. It's necessary for red blood cell production, but too much of it can contribute to clot formation. "High iron levels can promote oxidative stress, inflammation, and increased platelet aggregation—all of which make blood more prone to clotting," explains Dr. Padron. Unless your doctor diagnoses you with an iron deficiency, it's best to get iron from your diet. Reach for lean meats, legumes, and spinach, rather than a high-dose supplement.

3. Red Yeast Rice
Here's one you may not have heard of. Red yeast rice is seen as a natural alternative to statins, targeting high cholesterol levels—but it comes with potential risks, Dr. Padron warns. "Often used as a natural alternative to statins, red yeast rice contains monacolin K, which mimics the cholesterol-lowering effects of prescription drugs. However, in some people, it can lead to increased clot risk by altering blood lipid levels and causing unpredictable coagulation effects." He recommends talking to your doctor about safer ways to manage your cholesterol.

4. Omega-6 Fatty Acids
There are myriad benefits to omega-3 fatty acids. They can do wonders to relieve inflammation, for one. Omega-6 fatty acids, on the other hand, should be avoided in excess. "Excessive omega-6 intake (often in supplement form or from processed foods) can promote systemic inflammation, which in turn makes blood more prone to clotting." Instead of omega-6 supplements, Dr. Padron suggests balancing fatty acid intake by prioritizing omega-3-rich foods such as salmon, flaxseeds, and walnuts.

5. Ginseng
Ginseng is a popular supplement known for its energy-boosting and immune-supporting properties, but it may also pose a risk of blood clots. "Certain types (like Panax ginseng) may affect platelet function, potentially leading to increased clot risk. It can also interfere with blood-thinning medications, making them less effective," Dr. Padron says. For safer alternatives, he recommends staying hydrated, managing stress, and ensuring you get enough sleep each night to keep your energy levels stable the good old-fashioned way.

Bottom Line
If you are taking any of these supplements or considering adding them to your regimen, Dr. Padron recommends checking in with your doctor. "Blood clot risk isn’t just about one factor; it’s a combination of genetics, lifestyle, and medication interactions."
When in doubt, he says, aim to get your nutrients from whole food sources and focus on overall heart health. Hydration, regular movement, and adding anti-inflammatory foods to your plate are all great ways to maintain circulation and reduce clot risk.


