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Health

Experts Warn Women Over 40 To Be Careful With These 4 Supplements Because They Can Disrupt Hormones And Cause Weight Gain

July 11, 2026 by Faith Geiger
shefinds | Health
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Hormone levels naturally shift after 40, leading to common issues like stress and low energy to a slower metabolism and weight gain. Because of this, many women may reach for supplements promising to help ease these symptoms. But while there are plenty of helpful options out there, others may do more harm than good—especially when they interfere with the body’s delicate hormonal balance or make maintaining a healthy weight more difficult.

We spoke to Dr. Maral Malekzadeh, Board-Certified Gynecologist to learn about a few supplements that might throw your hormones off balance and result in weight gain. Find all of her warnings below.

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DHEA supplement for enhancing beauty and wellness.

1. DHEA (Dehydroepiandrosterone)

"DHEA (Dehydroepiandrosterone) is a hormone precursor that can increase estrogen and testosterone levels," Dr. Malekzadeh explains. This might lead to adverse effects like acne, an irregular menstrual cycle, changes, in mood, and hormonal imbalance.

DHEA could also contribute to weight fluctuations—including both weight loss and weight gain. Ultimately, Dr. Malekzadeh tells us, "It should only be used when clinically indicated."

Ashwagandha powder for stress relief and beauty benefits.

2. Ashwagandha

Ashwagandha is an increasingly popular natural supplement for people looking to lower stress levels. However, it could cause issues with your hormones. Dr. Malekzadeh explains that "it may increase thyroid hormone levels in some individuals and can affect cortisol regulation, making it inappropriate for people with certain thyroid or endocrine disorders."

Luckily, there are plenty of other ways to reduce stress.

High-dose soy isoflavones for hormonal balance in beauty.

3. High-dose soy isoflavones

According to Dr. Malekzadeh, concentrated phytoestrogen supplements "may influence estrogen receptor activity, particularly in people with hormone-sensitive conditions."

However, she says, "moderate dietary soy intake has not been shown to have these effects." Moderation is key!

Mass gainers and protein supplements for beauty and fitness.

4. Protein Supplements (Mass Gainers)

If you're looking to boost your protein intake or bulk up at the gym, you may reach for supplements known as "mass gainers." These are protein supplements with added sugars or maltodextrin, and Dr. Malekzadeh recommends being cautious of them.

"These products are often calorie-dense and can promote weight gain when consumed in excess due to their high carbohydrate and sugar content," she warns.

Doctor visit for beauty and health consultations.

Prioritize Natural Strategies

It's tempting to reach for supplements that promise to solve your problems, but Dr. Malekzadeh reminds us that natural strategies are always the best way to go.

"I recommend prioritizing lifestyle strategies that naturally support hormone health, including regular resistance exercise, adequate sleep, stress management, and a balanced diet with healthy fats from foods such as avocados, nuts, seeds, and olive oil." she says. "These approaches support normal hormone production without the risks associated with hormone supplementation."

We can definitely get behind that!

Author:

Freelance Writer

Faith Geiger is a New York-based writer and editor. When she's not covering the latest in health and wellness for SheFinds, she spends her time watching reality TV with her roommates, browsing used bookstores, and enjoying live music. You can reach Faith at faithkgeiger@gmail.com.

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Vitamins and supplements alongside water for daily health routine.
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Greek yogurt topped with assorted fresh fruits.
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Skin-glowing beverages recommended for women over 40.
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High-protein breakfast plate with eggs and vegetables.
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DJ Khaled celebrating at the Killing Castro premiere event.
Person waking up in the morning, ready to start the day.
Young woman enjoying chia seed yogurt for a healthy breakfast.
Stepping onto scale to track weight loss progress.
Vitamins and supplements alongside water for daily health routine.
Hand holding paper container filled with fresh salad greens.
Woman drinking water to stay hydrated during workout.
Older woman smiling after completing a workout session.
Woman enjoying green tea while working from home.
Greek yogurt topped with assorted fresh fruits.
Pouring coffee into a mug on a morning table.
Cooking crispy bacon in a frying pan.
Skin-glowing beverages recommended for women over 40.
Older woman stretching at home in preparation for exercise.
High-protein breakfast plate with eggs and vegetables.
Blueberry chia pudding in a clear glass bowl.
Poached eggs on herbed Greek yogurt with paprika oil.
Pretzel-coated chicken cutlets on a plate.
Healthy breakfast bowl with berries and chia seeds.
Doctor discussing GLP-1 medication with a patient.